Description
Product Characteristics:
Aliases: GUCY2D antibody, CORD6 antibody, GUC1A4 antibody, GUC2D antibody, RETGC antibody, RETGC1 antibody, Retinal guanylyl cyclase 1 antibody, RETGC-1 antibody, EC 4.6.1.2 antibody, CG-E antibody, Guanylate cyclase 2D antibody, retinal antibody, Rod outer segment membrane guanylate cyclase antibody, ROS-GC antibody
Target Information: This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]